Curar Animal Therapeutics | LIPUS therapy and how it works in cats, dogs and horses.

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LIPUS therapy and how it works in cats, dogs and horses.

November 20, 2013

Our review of low Intensity pulsed ultrasound and its use in accelerating healing in factures, tendon & ligament injuries in cats, dogs and horses was published  in the November publiation of Veterinary Practice.

LIPUS therapy and how it works in cats, dogs and horses.

The  Veterinary Practice magazine was amongst a number of specialist publications which ran a story about LIPUS treatment and Sonivet in their November publication to coincide with the London Vet Show.

The purpose of the article was to describe the mode of action behind Low Intensity Pulsed Ultrasound (LIPUS), how it differs from other ultrasound therapies in common use in veterinary practice and to describe some of the evidence which supports its use in promoting healing in tendon, ligament and fracture injuries in cats, dogs and horses.

Ultrasound has been a key component in an equine vet's armoury for sometime but the term covers a wide range of applications that use different wavelengths and intensities. 

LIPUS therapy has been shown to be effective in accelerating healing in damaged tendon, ligaments and fractures. In contrast, to therapeutic ultrasound, LIPUS uses a much lower intensity pulsed signal (0.03-0.1 W/cm2) and this has been shown to create micromechanical effects which result in biochemical events at the cellular level.  

Scientific studies have shown that the LIPUS waves travel through skin into the soft tissue and bone beneath, to the site of the injury and stimulate a biological response at the cellular level. For example: in osteoblasts (a crucial cell type that is implicated in bone healing), LIPUS signals have been shown cause integrins (cell membrane receptors found on all cells) to cluster on the cell membrane. These receptors are critical in the process of soft tissue and fracture repair as they initiate intracellular signalling. This signalling cascade results in the up-regulation of protein expression, and the release of factors that are essential to fracture healing and soft tissue repair, including PGE-2, COX-2, VEGF, BMP-4, BMP-7 and IGF-1, osteocalcin, osteonectin I, and osteopontin, alkaline phosphatase, MMP-13, and IGF-1. The end result is an accelerated, controlled healing response.

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